Viagra Extra Dosage 200mg

About Viagra 100 mg

What is Viagra used for?
Viagra’s active ingredient is a medication called sildenafil citrate. Sildenafil is a PDE-5 inhibitor used for the treatment of erectile dysfunction. Erectile dysfunction is the inability to have or maintain an erection sufficient enough or for long enough for satisfactory sexual performance.

How does Viagra work?
Viagra is a cGMP-specific phosphodiesterase type 5 (PDE5) inhibitor. Upon sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum which activates guanylate cyclase, an enzyme which causes the elevation of cyclic guanosine monophosphate (cGMP). This raised level of cGMP results in the relaxation of the smooth muscle of the corpus cavernosum allowing for improved blood flow.
Sildenafil acts to enhance the effect of the NO by inhibition of the PDE5 which is responsible for the breakdown of cGMP. This increase in cGMP results in further relaxation of the smooth muscle and increased blood flow to the penile area.

How do I take Viagra?
Viagra should be taken roughly 30 – 60 minutes prior to sexual activity. Do not use Viagra more than ONCE per day. The usual doses of Viagra is between 25 mg to 100 mg per dose. The maximum daily dose is 100 mg and should be taken as a single dose.
Viagra has an average half-life of around 4 hours but a range of 2 – 8 hours. This means Viagra will work longer or shorter for different people. According to manufacturer’s advice, you should engage in sexual activity from 30 minutes to 4 hours after you take a dose.

Can females take Viagra?
Viagra is not indicated for women. Viagra is therefore prescribed off-label if prescribed by a Doctor for a female. A recent study showed that although Viagra may be effective for sexual dysfunction in females it requires a physical arousal.

What are the side effects of Viagra?
Like all drugs, Viagra can cause some side-effects. The most common side-effects of Viagra are listed below; Headache
Nasal congestion
Facial flushing
Indigestion
Nausea
Abdominal pain
Dizziness
Throat tightness
Myalgia Pain in arms/legs
Dry mouth Somnolence

A Short History of Viagra, the accidental wonder drug
In the early 1990’s, clinical trials began to bring Viagra to market, but not for the indication it is now so famously known for. Scientists in Sandwich, UK, had been working to create a medication that would work on blocking the PDE5 enzyme to help treat cardiovascular issues such as Angina by way of vasodilating the arteries around the heart. In the early months of stage one in the clinical trials however, some peculiar effects that had not been anticipated were being observed. At the time, Ian Osterloh, the lead clinical researcher, noted that several men were getting erections days after the initial dose of the drug. His initial thought was even if it was true effect ‘who would want to take a drug on a Wednesday to get an erection on Saturday?’. However, as the trial progressed many of the trial nurses began reporting that a lot of the men taking the medication were laying on their stomach when they entered the room, and although mild abdominal cramps were being reported the red faced patients had another secret. Around the same time as these results were being reported a separate study was published uncovering the biochemical pathway of erections. This new literature backed the researchers hypothesis, that this new PDE5 inhibiting drug could prove to be a very effective medication for erectile dysfunction.
With millions of dollars already invested in the project it was a brave step to change the direction of the drug development. The research had understandably already attracted some publicity in light of these unexpected results and many ED sufferers had began writting to the research team outlining how important the medication would be for their well-being. This along with the undeniable, dose-response correlation results the research team were finding meant the research changed directions and 12 years after the initial project begun, 4 years after the first ED pilot, the Viagra we know today was brought to market.

Viagra Alternatives and other ED Drugs
Since the successful release of Viagra to the market there have been other successful ED drugs synthesized to work on the same PDE5 enzyme. These drugs have their similarities and differences to Viagra. The preference a patient may have for one of these drugs over another is often down to them trying the different ED medications and choosing the one that gives them optimal effect with the least side-effects.

Viagra vs Cialis
Cialis (tadalafil) was approved by the FDA in 2003, marketed originally as an ED drug, it’s licensed was later adapted to be indicated for treatment of pulmonary hypertension and benign prostatic hyperplasia (BPH). The key difference in terms of how Cialis compares with Viagra as an ED medication is in its half-life. Cialis, has a much longer half-life (17.5 hours) than Viagra (around 4 hours).